Mar 15, 2024
Transplanted human photoreceptors transfer cytoplasmic material but not to the recipient mouse retina
Stem cell research & therapy
CONCLUSIONS: While xenograft models are not a tractable system to study material transfer of human photoreceptors, these findings demonstrate that human retinal organoid-derived photoreceptors are competent donors for material transfer and thus may be useful to treat retinal degenerative disease.